| Route 81 | ||||
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| Route information | ||||
| Maintained by MoDOT | ||||
| Length: | 43 mi (69 km) | |||
| Major junctions | ||||
| South end: | Route 16 west of Canton | |||
| US 136 south of Kahoka Route Z north of Canton |
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| North end: | Iowa 81 near Farmington, IA | |||
| Highway system | ||||
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Missouri Highways
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Route 81 is a highway in northeastern Missouri. Its northern terminus is at the Iowa state line where it continues as Iowa Highway 81. Its southern terminus is at Route 16 west of Canton.